Structural Reshaping of the Zinc-Finger Domain of the SARS-CoV-2 nsp13 Protein Using Bismuth(III) Ions: A Multilevel Computational StudyArticle Published on 2022-10-032022-11-16 Journal: Inorganic chemistry [Category] COVID19(2023년), SARS, 변종, [키워드] analyses anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity classical decrease degrade domain Effect Efficacy Evidence evidenced extension feature Helicase hydrophobic immune Interaction Ion MD simulations MIF Modification molecular molecular interaction non-structural protein nsp12 protein nsp13 Occurrence pandemic Protein provide Research responsible SARS-COV-2 infection the SARS-CoV-2 the vaccine therapeutic strategy variants [DOI] 10.1021/acs.inorgchem.2c02685 PMC 바로가기
Dynamic mechanisms of CRISPR interference by Escherichia coli CRISPR-Cas3 Research Published on 2022-08-302022-10-05 Journal: Nature Communications [Category] 변종, 유전자 메커니즘, 진단, [키워드] atomic binding cleavage Complete complex CRISPR Degradation degrade detect DNA DNA degradation double-stranded dsDNA dynamic elicit Escherichia coli exhibit Genome in vitro mechanism Microscopy multi non-specific NTS nucleic acid PAM Partial priming Protein R-loop recruited Release sequence single-stranded DNA spacer ssDNA Type type I [DOI] 10.1038/s41467-022-32618-0 [Article Type] Research
Advancement and Challenges of Biosensing Using Field Effect Transistors전계효과 트랜지스터를 이용한 바이오센싱의 발전과 과제Review Published on 2022-08-172022-09-11 Journal: Biosensors [Category] SARS, 치료기술, [키워드] accompanied advancement approaches biosensors carried challenge coronavirus coronavirus disease COVID-19 pandemic Debye Debye length degrade Detection sensitivity Device direction domain Effect effective faster field field effect transistors field-effect transistor functional functionalization mechanism Microarray Modification modifications pace Pathogens provided raised SARS-CoV-2 spike protein Screening sensitivity specificity specificity. Spike protein surface area the SARS-CoV-2 transistor Transport [DOI] 10.3390/bios12080647 PMC 바로가기 [Article Type] Review
Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening Research Published on 2022-08-092022-10-05 Journal: Nature Communications [Category] 임상, 진단, [키워드] adaptive attenuate Bacteria CD169 cytokine degrade deplete detrimental downstream effector fungi G-CSF histone hyperinflammation hyphae immature immune dysfunction Immunity induce Infection infiltration Macrophage macrophages mechanism mechanism of action microbial Mortality myeloperoxidase neutralize neutrophil oxidative burst pathogen pathology Patient patient mortality phagocytic plasma promote receptor receptors Sepsis T cell Trigger zone [DOI] 10.1038/s41467-022-32320-1 [Article Type] Research
Characterization of SARS-CoV-2 replication complex elongation and proofreading activitySARS-CoV-2 복제 복합체 신장 및 교정 활성의 특성화Article Published on 2022-06-102022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral base pairs biochemical characterization complex coronavirus Critical dATP degrade drug elongation exonuclease experiment feature genomic sequence groups highlight incorporation inefficient inhibitor Mutation nsp10 nsp14 nucleotide nucleotides oligonucleotide promote Proofreading RdRP reduced Replication resulting ribose RNA RNA-dependent RNA polymerase RNA-dependent RNA polymerases SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 replication sequence shown target the SARS-CoV-2 Viral protein [DOI] 10.1038/s41598-022-13380-1 PMC 바로가기 [Article Type] Article
Detoxifying SARS-CoV-2 antiviral drugs from model and real wastewaters by industrial waste-derived multiphase photocatalysts산업폐기물 유래 다상 광촉매로 모델 폐수 및 실제 폐수에서 SARS-CoV-2 항바이러스제 해독Article Published on 2022-05-052022-09-11 Journal: Journal of hazardous materials [Category] COVID19(2023년), SARS, 치료제, [키워드] Ammonium antiviral drug antiviral drugs applied Combination Concentration contrary COVID-19 pandemic Danio Degradation degrade Effect effective Efficiency Embryo highest hydrophilic Industrial Industrial waste Lopinavir LOPINAVIR AND RITONAVIR Multiphase photocatalyst Photocatalysis plant reported resulting Ritonavir SARS-CoV-2 temperature tested Toxicity treated Treatment visible light wastewater water Water pollution Water purification Water purification. X-ray diffraction zebrafish [DOI] 10.1016/j.jhazmat.2022.128300 PMC 바로가기 [Article Type] Article
Immunotherapy and CRISPR Cas Systems: Potential Cure of COVID-19?면역 요법 및 CRISPR Cas 시스템: COVID-19의 잠재적 치료?Review Published on 2022-03-302022-09-11 Journal: Drug design, development and therapy [Category] MERS, SARS, 변종, 진단, [키워드] affected antibody CAR-T caused Cell cells circumvent clustered regularly interspaced short palindromic repeat condition convalescent plasma COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients COVID-19 treatment CRISPR CRISPR Cas cure degrade Disease progression feasible human body human immune response hypothese hypotheses Immune cell immune cells immune response immune responses Immunity Immunotherapy immunotherapy. individual infected individuals Infection Mild natural infection Neutralizing antibodies neutralizing antibody NK cells overcome pandemic Potential Prevent problem progression question raise risk SARS-CoV-2 SARS-COV-2 infection Severe case Side effects specificity Stage T cells treat Treatment Vaccine variants of concern Viral Viral RNA [DOI] 10.2147/DDDT.S347297 PMC 바로가기 [Article Type] Review
Rapid Degradation of SARS-CoV-2 Spike S Protein by A Specific Serine Protease특정 세린 프로테아제에 의한 SARS-CoV-2 스파이크 S 단백질의 빠른 분해Article Published on 2022-03-142022-09-11 Journal: Molecules [Category] SARS, 변종, [키워드] Acidic alkaline alkaline serine protease with an acidic pI (ASPNJ) Antiviral antiviral agent arginine ASP carbonyl cleave contributed COVID-19 Degradation degradation of S protein degrade experiment functional in vitro lysine macroscopic Mutation new treatment strategy peptide Peptide bond Prevent Protein purified Rapid RBD of SARS-CoV-2 S protein S1 subunit SARS-CoV-2 SARS-CoV-2 variants SARS-CoV-2 virus SDS-PAGE Serine serine protease Specific spike spike (S) protein. the S protein the S1 subunit variant virus virus entry wild-type SARS-CoV-2 [DOI] 10.3390/molecules27061882 PMC 바로가기 [Article Type] Article
Effective degradation of COVID-19 related drugs by biochar-supported red mud catalyst activated persulfate process: Mechanism and pathwayResearch article Published on 2022-03-012022-10-05 Journal: Journal of Cleaner Production [Category] 치료제, [키워드] activated ARB Arbidol Biochar caused Chloroquine phosphate condition conditions COVID-19 COVID-19 pandemic COVID-19 related drugs Degradation degrade demonstrated drug drugs Effect effective experiments Fourier transform functional group hydroxychloroquine sulfate hydroxyl group indicated investigated pathway Persulfate predominant Red mud residue responsible Spread [DOI] 10.1016/j.jclepro.2022.130753 [Article Type] Research article
A one-step platform for screening high-efficient and minimal off-target CRISPR/Cas13 crRNAs to eradicate SARS-CoV-2 virus for treatment of COVID-19 patientsCOVID-19 환자 치료를 위해 SARS-CoV-2 바이러스를 근절하기 위해 고효율 및 최소 표적 외 CRISPR/Cas13 crRNA를 스크리닝하기 위한 1단계 플랫폼Article Published on 2022-02-012022-09-11 Journal: Medical Hypotheses [Category] COVID19(2023년), SARS, 변종, 신약개발, 진단, 치료기술, 치료법, 치료제, [키워드] ACE2 ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Algorithm angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral applied caused cleavage clustered regularly interspaced short palindromic repeats coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19, Coronavirus disease 2019 CRISPR CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats CRISPR/Cas13 Degradation degrade develop diagnostics disease Effect effective enzyme foundation Gene Expression identify Nuclease Palindromic platform positive-sense Protein provide Replication respiratory Respiratory illness RNA RNA genome RNA viruses RNA-Seq SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 scRNA-seq scRNA-seq, Single-cell RNA-seq. severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single-cell RNA-seq Spread SRAS-CoV-2 target targeting Therapeutics treat Treatment Type viral genome viral mRNA viral mRNAs Viral RNA virus elimination [DOI] 10.1016/j.mehy.2021.110754 PMC 바로가기 [Article Type] Article